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Action time profile of Insulin preparations
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Action time profile of Insulin preparations

 

Insulin is injected in fat below skin and then it reaches blood circulation. The rate of insulin entry in blood and its duration differs with the different Insulin preparations. That is ,  after injecting , Insulin starts rising after few minutes and this is called time of onset, then after some time maximum concentration is achieved and this is called peak time , then at last Insulin level starts decreasing in blood and after some hours no more Insulin is left there and this is mentioned as duration of action.

 

Below mentioned table gives complete information about time action of various Insulin types:

Insulin Types

Human Insulin & Insulin Analogs

onset

peak

duration

Rapid - Acting Analogs

  • Insulin lispro (Humalog)
  • Insulin aspart (NovoLog)
  • Insulin glulisine (Apidra)

 

10-15 min

10-15 min

10-15 min

 

1-2 hrs

1-2 hrs

1-2 hrs

 

3-5 hrs

3-5 hrs

3-5 hrs

Short Acting

  • Regular

 

0.5 - 1 hr

 

2-4 hrs

 

4-8 hrs

Intermediate - Acting

  • NPH

 

1-3 hrs

 

4-10 hrs

 

10-18 hrs

Long-Acting Analogs

  • Insulin glargine (Lantus)
  • Insulin detemir (Levemir)

 

2-3 hrs

1 hr

 

none

none

 

24+ hrs

Up to 24 hrs

Pre-Mixed Insulin’s Conventional

  • 30/70 (30% Regular +70%NPH)
  • 50/50 (50% Regular+50% NPH)
  • 25/75 (25% Regular+75% NPH)

 

0.5 -1 hr

0.5 -1 hr

0.5 -1 hr

 

 

2-10 hrs

2-10 hrs

2-10 hrs

 

 

10-18 hrs

10-18 hrs

10-18 hrs

Pre-Mixed Insulin’s Analog

  • Humalog Mix 25/75(25% lispro + 75% lispro protamine)
  • Humalog Mix 50/50 (50% lispro +50% lispro protamine)
  • NovoLog Mix/Novomix 30/70 (30% aspart +70% aspart protamine)

 

10-15 min

 

10-15 min

 

10-20 min

 

1-3 hrs

 

1-3 hrs

 

1-4 hrs

 

10-16 hrs

 

10-16 hrs

 

10-16 hrs

 

 

 
  
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