Action time profile of Insulin preparations
Insulin is injected in fat below skin and then it reaches blood circulation. The rate of insulin entry in blood and its duration differs with the different Insulin preparations. That is , after injecting , Insulin starts rising after few minutes and this is called time of onset, then after some time maximum concentration is achieved and this is called peak time , then at last Insulin level starts decreasing in blood and after some hours no more Insulin is left there and this is mentioned as duration of action.
Below mentioned table gives complete information about time action of various Insulin types:
Insulin Types
|
Human Insulin & Insulin Analogs |
onset |
peak |
duration |
|
Rapid - Acting Analogs
- Insulin lispro (Humalog)
- Insulin aspart (NovoLog)
- Insulin glulisine (Apidra)
|
10-15 min
10-15 min
10-15 min |
1-2 hrs
1-2 hrs
1-2 hrs |
3-5 hrs
3-5 hrs
3-5 hrs |
|
Short Acting
|
0.5 - 1 hr |
2-4 hrs |
4-8 hrs |
|
Intermediate - Acting
|
1-3 hrs |
4-10 hrs |
10-18 hrs |
|
Long-Acting Analogs
- Insulin glargine (Lantus)
- Insulin detemir (Levemir)
|
2-3 hrs
1 hr |
none
none |
24+ hrs
Up to 24 hrs |
|
Pre-Mixed Insulin’s Conventional
- 30/70 (30% Regular +70%NPH)
- 50/50 (50% Regular+50% NPH)
- 25/75 (25% Regular+75% NPH)
|
0.5 -1 hr
0.5 -1 hr
0.5 -1 hr
|
2-10 hrs
2-10 hrs
2-10 hrs
|
10-18 hrs
10-18 hrs
10-18 hrs |
|
Pre-Mixed Insulin’s Analog
- Humalog Mix 25/75(25% lispro + 75% lispro protamine)
- Humalog Mix 50/50 (50% lispro +50% lispro protamine)
- NovoLog Mix/Novomix 30/70 (30% aspart +70% aspart protamine)
|
10-15 min
10-15 min
10-20 min |
1-3 hrs
1-3 hrs
1-4 hrs |
10-16 hrs
10-16 hrs
10-16 hrs
|